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Featured Publications

Stem cell–derived CAR T cells traffic to HIV reservoirs in macaques

Barber-Axthelm et al. JCI Insight.
January 11, 2021

We demonstrate that HSC-derived CAR+ cells reside long-term and proliferate in numerous tissues relevant for HIV infection and cancer.

JCI Insights_Baber-Anxthem, Peterson, Ki

Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation

Cardozo-Ojeda et al. ELife.
January 12, 2021

Our mathematical model predicts when viral control can be obtained following analytical treatment interruption (ATI).

Gene Transfer in Adeno-Associated Virus Seropositive Rhesus Macaques Following Rapamycin Treatment and Subcutaneous Delivery of AAV6, but Not Retargeted AAV6 Vectors

Stone et al. Molecular Therapy Methods & Clinical Development.
January 18, 2021

Our study provides important safety and efficacy data that will aid study design for future anti-HIV gene therapies.

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Safe and Effective In Vivo Targeting and Gene Editing in Hematopoietic Stem Cells: Strategies for Accelerating Development

Cannon et al. Human Gene Therapy.
January 18, 2021

On May 11, 2020, the NIH and the Gates Foundation held an exploratory expert scientific roundtable on the development of scalable, sustainable, and accessible HIV and sickle cell disease (SCD) therapies based on in vivo gene editing of hematopoietic stem cells (HSCs), emphasizing how such therapies could be developed for low-resource settings in sub-Saharan Africa.

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Lessons from London and Berlin: Designing A Scalable Gene Therapy Approach for HIV Cure

Christopher W. Peterson, Hans-Peter Kiem
Cell Stem Cell
May 2, 2019

Here we comment on the 2019 report in Nature, by Gupta et al., describing the London Patient. We compare this case with the Berlin Patient (Timothy Brown) and summarize efforts to develop a broader and more patient-freindly approach.

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Cell and Gene Therapy for HIV Cure

Christopher W. Peterson, Hans-Peter Kiem.
Current Topics in Microbiology and Immunology.
December 19, 2017

This chapter in Current Topics in Microbiology and Immunology outlines cell and gene therapy strategies that are poised to play an essential role in eradicating HIV-infected cells in vivo.

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Publications: News

All Publications

Publications: Text

2021

Stone D, Long KR, Loprieno MA, De Silva Feelixge HS, Kenkel EJ, Liley RM, Rapp S, Roychoudhury P, Nguyen T, Stensland L, Colon-Thillet R, Klouser LM, Weber ND, Le C, Wagoner J, Goecker EA, Li AZ, Eichholz K, Corey L, Tyrrell DL, Greninger AL, Huang ML, Polyak SJ, Aubert M, Sagartz JE, Jerome KR. CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice. Mol Ther Methods Clin Dev. 2021;20:258-75. Epub 2021/01/22. doi: 10.1016/j.omtm.2020.11.014. PubMed PMID: 33473359; PMCID: PMC7803634.

Stone D, Kenkel EJ, Loprieno MA, Tanaka M, De Silva Feelixge HS, Kumar AJ, Stensland L, Obenza WM, Wangari S, Ahrens CY, Murnane RD, Peterson CW, Kiem HP, Huang ML, Aubert M, Hu SL, Jerome KR. Gene Transfer in Adeno-Associated Virus Seropositive Rhesus Macaques Following Rapamycin Treatment and Subcutaneous Delivery of AAV6, but Not Retargeted AAV6 Vectors. Hum Gene Ther. 2021 Jan;32(1-2):96-112. doi: 10.1089/hum.2020.113. Epub 2020 Nov 2. PubMed PMID: 32998579.

Cardozo-Ojeda EF, Duke ER, Peterson CW, Reeves DB, Mayer BT, Kiem HP, Schiffer JT. Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation. Elife. 2021;10. Epub 2021/01/13. doi: 10.7554/eLife.57646. PubMed PMID: 33432929; PMCID: PMC7803377.

Barber-Axthelm IM, Barber-Axthelm V, Sze KY, Zhen A, Suryawanshi GW, Chen IS, Zack JA, Kitchen SG, Kiem HP, Peterson CW. Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques. JCI Insight. 2021;6(1). Epub 2021/01/12. doi: 10.1172/jci.insight.141502. PubMed PMID: 33427210; PMCID: PMC7821595.

Humbert O, Samuelson C, Kiem HP. CRISPR/Cas9 for the treatment of haematological diseases: a journey from bacteria to the bedside. Br J Haematol. 2021;192(1):33-49. Epub 2020/06/09. doi: 10.1111/bjh.16807. PubMed PMID: 32506752.

Publications: Text

2020

Dube K, Willenberg L, Dee L, Sylla L, Taylor J, Roebuck C, Palm D, Campbell D, Newton L, Patel H, Perry KE, Kanazawa J, Gerrard J, Brown B, Saberi P, Sauceda JA, Peluso MJ. Re-examining the HIV 'functional cure' oxymoron: Time for precise terminology? Journal of virus eradication. 2020;6(4):100017. Epub 2020/12/01. doi: 10.1016/j.jve.2020.100017. PubMed PMID: 33251025; PMCID: PMC7646673.

Haeseleer F, Eichholz K, Tareen SU, Iwamoto N, Roederer M, Kirchhoff F, Park H, Okoye AA, Corey L. Real-Time Killing Assays to Assess the Potency of a New Anti-Simian Immunodeficiency Virus Chimeric Antigen Receptor T Cell. AIDS Res Hum Retroviruses. 2020;36(12):998-1009. Epub 2020/09/30. doi: 10.1089/AID.2020.0163. PubMed PMID: 32988211; PMCID: PMC7703091.

Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, 2nd, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J, lung-network@humancellatlas.org HCALBNEa, Network HCALB. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 2020;181(5):1016-35 e19. Epub 2020/05/16. doi: 10.1016/j.cell.2020.04.035. PubMed PMID: 32413319; PMCID: PMC7252096.

Hsiao F, Frouard J, Gramatica A, Xie G, Telwatte S, Lee GQ, Roychoudhury P, Schwarzer R, Luo X, Yukl SA, Lee S, Hoh R, Deeks SG, Jones RB, Cavrois M, Greene WC, Roan NR. Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. PLoS Pathog. 2020;16(4):e1008450. Epub 2020/05/01. doi: 10.1371/journal.ppat.1008450. PubMed PMID: 32353080; PMCID: PMC7192375.

Antar AA, Jenike KM, Jang S, Rigau DN, Reeves DB, Hoh R, Krone MR, Keruly JC, Moore RD, Schiffer JT, Nonyane BA, Hecht FM, Deeks SG, Siliciano JD, Ho YC, Siliciano RF. Longitudinal study reveals HIV-1-infected CD4+ T cell dynamics during long-term antiretroviral therapy. J Clin Invest. 2020;130(7):3543-59. Epub 2020/03/20. doi: 10.1172/JCI135953. PubMed PMID: 32191639; PMCID: PMC7324206.

Reeves DB, Huang Y, Duke ER, Mayer BT, Cardozo-Ojeda EF, Boshier FA, Swan DA, Rolland M, Robb ML, Mascola JR, Cohen MS, Corey L, Gilbert PB, Schiffer JT. Mathematical modeling to reveal breakthrough mechanisms in the HIV Antibody Mediated Prevention (AMP) trials. PLoS Comput Biol. 2020;16(2):e1007626. Epub 2020/02/23. doi: 10.1371/journal.pcbi.1007626. PubMed PMID: 32084132; PMCID: PMC7055956.

Pankau MD, Reeves DB, Harkins E, Ronen K, Jaoko W, Mandaliya K, Graham SM, McClelland RS, Matsen Iv FA, Schiffer JT, Overbaugh J, Lehman DA. Dynamics of HIV DNA reservoir seeding in a cohort of superinfected Kenyan women. PLoS Pathog. 2020;16(2):e1008286. Epub 2020/02/06. doi: 10.1371/journal.ppat.1008286. PubMed PMID: 32023326; PMCID: PMC7028291.

Davis-Gardner ME, Alfant B, Weber JA, Gardner MR, Farzan M. A Bispecific Antibody That Simultaneously Recognizes the V2- and V3-Glycan Epitopes of the HIV-1 Envelope Glycoprotein Is Broader and More Potent than Its Parental Antibodies. mBio. 2020;11(1). Epub 2020/01/16. doi: 10.1128/mBio.03080-19. PubMed PMID: 31937648; PMCID: PMC6960291.

Publications: Text

2019

Gardner MR, Fellinger CH, Kattenhorn LM, Davis-Gardner ME, Weber JA, Alfant B, Zhou AS, Prasad NR, Kondur HR, Newton WA, Weisgrau KL, Rakasz EG, Lifson JD, Gao G, Schultz-Darken N, Farzan M. AAV-delivered eCD4-Ig protects rhesus macaques from high-dose SIVmac239 challenges. Sci Transl Med. 2019;11(502). Epub 2019/07/26. doi: 10.1126/scitranslmed.aau5409. PubMed PMID: 31341061; PMCID: PMC6716512.

Peterson CW, Adair JE, Wohlfahrt ME, Deleage C, Radtke S, Rust B, Norman KK, Norgaard ZK, Schefter LE, Sghia-Hughes GM, Repetto A, Baldessari A, Murnane RD, Estes JD, Kiem HP. Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants. Stem Cell Reports. 2019;13(1):91-104. Epub 2019/06/18. doi: 10.1016/j.stemcr.2019.05.016. PubMed PMID: 31204301; PMCID: PMC6626873.

Newton L, Necochea R, Palm D, Taylor J, Barr L, Patel H, Nathan A, Gerrard J, Sylla L, Brown B, Dube K. Revisiting the 'sterilising cure' terminology: a call for more patient-centred perspectives on HIV cure-related research. J Virus Erad. 2019;5(2):122-4. Epub 2019/06/14. PubMed PMID: 31191916; PMCID: PMC6543486.

Fellinger CH, Gardner MR, Weber JA, Alfant B, Zhou AS, Farzan M. eCD4-Ig Limits HIV-1 Escape More Effectively than CD4-Ig or a Broadly Neutralizing Antibody. J Virol. 2019;93(14). Epub 2019/05/10. doi: 10.1128/JVI.00443-19. PubMed PMID: 31068428; PMCID: PMC6600210.

Dube K, Simoni J, Louella M, Sylla L, Mohamed ZH, Patel H, Luter S, Collier AC. Acceptability of Cell and Gene Therapy for Curing HIV Infection Among People Living with HIV in the Northwestern United States: A Qualitative Study. AIDS Res Hum Retroviruses. 2019;35(7):649-59. Epub 2019/04/17. doi: 10.1089/AID.2019.0021. PubMed PMID: 30990052; PMCID: PMC6602097.

Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Nikic-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB, 3rd, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W. Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET. Nature. 2019;568(7752):415-9. Epub 2019/04/12. doi: 10.1038/s41586-019-1101-y. PubMed PMID: 30971821; PMCID: PMC6655592.

Cao S, Slack SD, Levy CN, Hughes SM, Jiang Y, Yogodzinski C, Roychoudhury P, Jerome KR, Schiffer JT, Hladik F, Woodrow KA. Hybrid nanocarriers incorporating mechanistically distinct drugs for lymphatic CD4(+) T cell activation and HIV-1 latency reversal. Sci Adv. 2019;5(3):eaav6322. Epub 2019/04/05. doi: 10.1126/sciadv.aav6322. PubMed PMID: 30944862; PMCID: PMC6436934.

Gardner MR, Fetzer I, Kattenhorn LM, Davis-Gardner ME, Zhou AS, Alfant B, Weber JA, Kondur HR, Martinez-Navio JM, Fuchs SP, Desrosiers RC, Gao G, Lifson JD, Farzan M. Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies. Mol Ther. 2019;27(3):650-60. Epub 2019/02/02. doi: 10.1016/j.ymthe.2019.01.004. PubMed PMID: 30704961; PMCID: PMC6403482.

Fetzer I, Davis-Gardner ME, Gardner MR, Alfant B, Weber JA, Prasad NR, Zhou AS, Farzan M. A Coreceptor-Mimetic Peptide Enhances the Potency of V3-Glycan Antibodies. J Virol. 2019;93(5). Epub 2018/12/14. doi: 10.1128/JVI.01653-18. PubMed PMID: 30541842; PMCID: PMC6384058.

O'Connor MA, Munson PV, Tunggal HC, Hajari N, Lewis TB, Bratt D, Moats C, Smedley J, Bagley KC, Mullins JI, Fuller DH. Mucosal T Helper 17 and T Regulatory Cell Homeostasis Correlate with Acute Simian Immunodeficiency Virus Viremia and Responsiveness to Antiretroviral Therapy in Macaques. AIDS Res Hum Retroviruses. 2019;35(3):295-305. Epub 2018/11/07. doi: 10.1089/AID.2018.0184. PubMed PMID: 30398361; PMCID: PMC6434588.

Kuhlmann AS, Haworth KG, Barber-Axthelm IM, Ironside C, Giese MA, Peterson CW, Kiem HP. Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice. Mol Ther. 2019;27(1):164-77. Epub 2018/11/06. doi: 10.1016/j.ymthe.2018.09.017. PubMed PMID: 30391142; PMCID: PMC6318702.

Publications: Text

2018

Wagner TA. Quarter Century of Anti-HIV CAR T Cells. Curr HIV/AIDS Rep. 2018;15(2):147-54. Epub 2018/03/04. doi: 10.1007/s11904-018-0388-x. PubMed PMID: 29500712; PMCID: PMC5884727.

Sylla L, Evans D, Taylor J, Gilbertson A, Palm D, Auerbach JD, Dube K. If We Build It, Will They Come? Perceptions of HIV Cure-Related Research by People Living with HIV in Four U.S. Cities: A Qualitative Focus Group Study. AIDS research and human retroviruses. 2018;34(1):56-66. Epub 2017/12/05. doi: 10.1089/AID.2017.0178. PubMed PMID: 29198134; PMCID: PMC5771509.

Roychoudhury P, De Silva Feelixge H, Reeves D, Mayer BT, Stone D, Schiffer JT, Jerome KR. Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoir. BMC Biol. 2018;16(1):75. Epub 2018/07/13. doi: 10.1186/s12915-018-0544-1. PubMed PMID: 29996827; PMCID: PMC6040082.

Reeves DB, Duke ER, Wagner TA, Palmer SE, Spivak AM, Schiffer JT. A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation. Nature communications. 2018;9(1):4811. Epub 2018/11/18. doi: 10.1038/s41467-018-06843-5. PubMed PMID: 30446650; PMCID: PMC6240116.

Peterson CW, Wang J, Deleage C, Reddy S, Kaur J, Polacino P, Reik A, Huang ML, Jerome KR, Hu SL, Holmes MC, Estes JD, Kiem HP. Differential impact of transplantation on peripheral and tissue-associated viral reservoirs: Implications for HIV gene therapy. PLoS Pathog. 2018;14(4):e1006956. Epub 2018/04/20. doi: 10.1371/journal.ppat.1006956. PubMed PMID: 29672640; PMCID: PMC5908070.

Paul B, Ibarra GSR, Hubbard N, Einhaus T, Astrakhan A, Rawlings DJ, Kiem HP, Peterson CW. Efficient Enrichment of Gene-Modified Primary T Cells via CCR5-Targeted Integration of Mutant Dihydrofolate Reductase. Molecular therapy Methods & clinical development. 2018;9:347-57. Epub 2018/07/25. doi: 10.1016/j.omtm.2018.04.002. PubMed PMID: 30038938; PMCID: PMC6054698.

Kuhlmann AS, Peterson CW, Kiem HP. Chimeric antigen receptor T-cell approaches to HIV cure. Current opinion in HIV and AIDS. 2018;13(5):446-53. Epub 2018/06/08. doi: 10.1097/COH.0000000000000485. PubMed PMID: 29878913; PMCID: PMC6993924.

Fetzer I, Gardner MR, Davis-Gardner ME, Prasad NR, Alfant B, Weber JA, Farzan M. eCD4-Ig Variants That More Potently Neutralize HIV-1. Journal of virology. 2018;92(12). Epub 2018/03/30. doi: 10.1128/JVI.02011-17. PubMed PMID: 29593050; PMCID: PMC5974481.

Dube K, Evans D, Dee L, Sylla L, Taylor J, Skinner A, Weiner BJ, Greene SB, Rennie S, Tucker JD. "We Need to Deploy Them Very Thoughtfully and Carefully": Perceptions of Analytical Treatment Interruptions in HIV Cure Research in the United States-A Qualitative Inquiry. AIDS research and human retroviruses. 2018;34(1):67-79. Epub 2017/06/01. doi: 10.1089/AID.2017.0067. PubMed PMID: 28562069; PMCID: PMC5771546.

Dube K, Dee L, Evans D, Sylla L, Taylor J, Brown B, Miller V, Corneli A, Skinner A, Greene SB, Tucker JD, Rennie S. Perceptions of Equipoise, Risk-Benefit Ratios, and "Otherwise Healthy Volunteers" in the Context of Early-Phase HIV Cure Research in the United States: A Qualitative Inquiry. J Empir Res Hum Res Ethics. 2018;13(1):3-17. Epub 2017/10/07. doi: 10.1177/1556264617734061. PubMed PMID: 28984168; PMCID: PMC5768449.

De Silva Feelixge HS, Stone D, Roychoudhury P, Aubert M, Jerome KR. CRISPR/Cas9 and Genome Editing for Viral Disease-Is Resistance Futile? ACS Infect Dis. 2018;4(6):871-80. Epub 2018/03/10. doi: 10.1021/acsinfecdis.7b00273. PubMed PMID: 29522311; PMCID: PMC5993632.

Colonna L, Peterson CW, Schell JB, Carlson JM, Tkachev V, Brown M, Yu A, Reddy S, Obenza WM, Nelson V, Polacino PS, Mack H, Hu SL, Zeleski K, Hoffman M, Olvera J, Furlan SN, Zheng H, Taraseviciute A, Hunt DJ, Betz K, Lane JF, Vogel K, Hotchkiss CE, Moats C, Baldessari A, Murnane RD, English C, Astley CA, Wangari S, Agricola B, Ahrens J, Iwayama N, May A, Stensland L, Huang MW, Jerome KR, Kiem HP, Kean LS. Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation. Nature communications. 2018;9(1):4438. Epub 2018/10/27. doi: 10.1038/s41467-018-06736-7. PubMed PMID: 30361514; PMCID: PMC6202377.

Cardozo EF, Apetrei C, Pandrea I, Ribeiro RM. The dynamics of simian immunodeficiency virus after depletion of CD8+ cells. Immunol Rev. 2018;285(1):26-37. Epub 2018/08/22. doi: 10.1111/imr.12691. PubMed PMID: 30129200; PMCID: PMC6352983.

Publications: Text

2017

Reeves DB, Peterson CW, Kiem HP, Schiffer JT. Autologous Stem Cell Transplantation Disrupts Adaptive Immune Responses during Rebound Simian/Human Immunodeficiency Virus Viremia. Journal of virology. 2017;91(13). Epub 2017/04/14. doi: 10.1128/JVI.00095-17. PubMed PMID: 28404854; PMCID: PMC5469274.

Reeves DB, Duke ER, Hughes SM, Prlic M, Hladik F, Schiffer JT. Anti-proliferative therapy for HIV cure: a compound interest approach. Scientific reports. 2017;7(1):4011. Epub 2017/06/24. doi: 10.1038/s41598-017-04160-3. PubMed PMID: 28638104; PMCID: PMC5479830.

Peterson CW, Benne C, Polacino P, Kaur J, McAllister CE, Filali-Mouhim A, Obenza W, Pecor TA, Huang ML, Baldessari A, Murnane RD, Woolfrey AE, Jerome KR, Hu SL, Klatt NR, DeRosa S, Sekaly RP, Kiem HP. Loss of immune homeostasis dictates SHIV rebound after stem-cell transplantation. JCI insight. 2017;2(4):e91230. Epub 2017/02/28. doi: 10.1172/jci.insight.91230. PubMed PMID: 28239658; PMCID: PMC5322807.

Niyonzima N, Lambert AR, Werther R, De Silva Feelixge H, Roychoudhury P, Greninger AL, Stone D, Stoddard BL, Jerome KR. Tuning DNA binding affinity and cleavage specificity of an engineered gene-targeting nuclease via surface display, flow cytometry and cellular analyses. Protein engineering, design & selection : PEDS. 2017;30(7):503-22. Epub 2017/09/07. doi: 10.1093/protein/gzx037. PubMed PMID: 28873986; PMCID: PMC5914421.

Hale M, Mesojednik T, Romano Ibarra GS, Sahni J, Bernard A, Sommer K, Scharenberg AM, Rawlings DJ, Wagner TA. Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2017;25(3):570-9. Epub 2017/02/02. doi: 10.1016/j.ymthe.2016.12.023. PubMed PMID: 28143740; PMCID: PMC5363191.

Gardner MR, Farzan M. Engineering antibody-like inhibitors to prevent and treat HIV-1 infection. Current opinion in HIV and AIDS. 2017;12(3):294-301. Epub 2017/04/20. doi: 10.1097/COH.0000000000000367. PubMed PMID: 28422793; PMCID: PMC5389584.

Fellinger CH, Gardner MR, Bailey CC, Farzan M. Simian Immunodeficiency Virus SIVmac239, but Not SIVmac316, Binds and Utilizes Human CD4 More Efficiently than Rhesus CD4. Journal of virology. 2017;91(18). Epub 2017/07/07. doi: 10.1128/JVI.00847-17. PubMed PMID: 28679752; PMCID: PMC5571245.

Dube K, Taylor J, Sylla L, Evans D, Dee L, Burton A, Willenberg L, Rennie S, Skinner A, Tucker JD, Weiner BJ, Greene SB. 'Well, It's the Risk of the Unknown... Right?': A Qualitative Study of Perceived Risks and Benefits of HIV Cure Research in the United States. PloS one. 2017;12(1):e0170112. Epub 2017/01/26. doi: 10.1371/journal.pone.0170112. PubMed PMID: 28122027; PMCID: PMC5266311.

Dube K, Sylla L, Dee L, Taylor J, Evans D, Bruton CD, Gilberston A, Gralinski L, Brown B, Skinner A, Weiner BJ, Greene SB, Corneli A, Adimora AA, Tucker JD, Rennie S. Research on HIV cure: Mapping the ethics landscape. PLoS Med. 2017;14(12):e1002470. Epub 2017/12/09. doi: 10.1371/journal.pmed.1002470. PubMed PMID: 29220353; PMCID: PMC5722280.

Dube K, Evans D, Sylla L, Taylor J, Weiner BJ, Skinner A, Thirumurthy H, Tucker JD, Rennie S, Greene SB. Willingness to participate and take risks in HIV cure research: survey results from 400 people living with HIV in the US. Journal of virus eradication. 2017;3(1):40-50 e21. Epub 2017/03/10. PubMed PMID: 28275457; PMCID: PMC5337420.

De Silva Feelixge HS, Jerome KR. Excision of Latent HIV-1 from Infected Cells In Vivo: An Important Step Forward. Molecular therapy : the journal of the American Society of Gene Therapy. 2017;25(5):1062-4. Epub 2017/05/04. doi: 10.1016/j.ymthe.2017.04.009. PubMed PMID: 28462817; PMCID: PMC5417841.

Davis-Gardner ME, Gardner MR, Alfant B, Farzan M. eCD4-Ig promotes ADCC activity of sera from HIV-1-infected patients. PLoS Pathog. 2017;13(12):e1006786. Epub 2017/12/19. doi: 10.1371/journal.ppat.1006786. PubMed PMID: 29253851; PMCID: PMC5749896.

Dang CH, Aubert M, De Silva Feelixge HS, Diem K, Loprieno MA, Roychoudhury P, Stone D, Jerome KR. In vivo dynamics of AAV-mediated gene delivery to sensory neurons of the trigeminal ganglia. Scientific reports. 2017;7(1):927. Epub 2017/04/21. doi: 10.1038/s41598-017-01004-y. PubMed PMID: 28424485; PMCID: PMC5430444.

Publications: Text

2016

Spragg C, De Silva Feelixge H, Jerome KR. Cell and gene therapy strategies to eradicate HIV reservoirs. Current opinion in HIV and AIDS. 2016;11(4):442-9. Epub 2016/04/01. doi: 10.1097/COH.0000000000000284. PubMed PMID: 27031009; PMCID: PMC4913694.

Jerome KR. Disruption or Excision of Provirus as an Approach to HIV Cure. AIDS patient care and STDs. 2016;30(12):551-5. Epub 2016/11/18. doi: 10.1089/apc.2016.0232. PubMed PMID: 27855263; PMCID: PMC5144885.

Gardner MR, Fellinger CH, Prasad NR, Zhou AS, Kondur HR, Joshi VR, Quinlan BD, Farzan M. CD4-Induced Antibodies Promote Association of the HIV-1 Envelope Glycoprotein with CD4-Binding Site Antibodies. Journal of virology. 2016;90(17):7822-32. Epub 2016/06/24. doi: 10.1128/JVI.00803-16. PubMed PMID: 27334589; PMCID: PMC4988152.

Aubert M, Madden EA, Loprieno M, DeSilva Feelixge HS, Stensland L, Huang ML, Greninger AL, Roychoudhury P, Niyonzima N, Nguyen T, Magaret A, Galleto R, Stone D, Jerome KR. In vivo disruption of latent HSV by designer endonuclease therapy. JCI insight. 2016;1(14). Epub 2016/09/20. doi: 10.1172/jci.insight.88468. PubMed PMID: 27642635; PMCID: PMC5026126.

Publications: Text

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