Cake, candles and a wish for more HIV cures

Posted on February 23, 2017 by defeatHIV

Cake, candles and a wish for more HIV cures An HIV workshop pays tribute to Timothy Ray Brown, whose cure 10 years ago fueled research — and hope Feb. 13, 2017 | By Mary Engel / Fred Hutch News Service Timothy Ray Brown celebrates his 10th “birthday,” marking the anniversary of the stem cell transplant that […]

Read more

Can immunotherapy cure HIV?

Posted on August 18, 2016 by defeatHIV

Hutch News Can immunotherapy cure HIV? A revolution in cancer care may offer clues to a cure or remission for HIV/AIDS Aug. 8, 2016 | By Mary Engel / Fred Hutch News Service Dr. Rowena Johnston, vice president and director of research for the Foundation for AIDS Research, addresses the third annual Conference on […]

Read more

defeatHIV Receives Second Round of Funding from NIH

Posted on July 13, 2016 by defeatHIV

This article was originally published on Fred Hutch HIV cure program extended, expanded DefeatHIV receives second five-year grant from NIH to research gene and cell therapies July 13, 2016 By Mary Engel / Fred Hutch News Service Dr. Keith Jerome, left, and Dr. Hans-Peter Kiem are the co-directors of defeatHIV. Photo by Robert […]

Read more

Conference on Cell & Gene Therapy for HIV Cure 2016

Posted on July 12, 2016 by defeatHIV

3rd Annual Conference on Cell & Gene Therapy for HIV Cure to be held August 4-5, 2016 in Seattle, WA WEBSITE DATES Pre-Conference Community Event: August 3, 2016 Conference: August 4-5, 2016 LOCATION Fred Hutchinson Cancer Research Center Seattle, WA USA We are pleased to announce the 3rd Conference on Cell & Gene Therapy […]

Read more

Publication Spotlight: Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

Posted on May 28, 2016 by defeatHIV

Genome editing in hematopoietic stem and progenitor cells (HSPCs) is a promising novel technology for the treatment of many human diseases. Here, we evaluated whether the disruption of the C-C chemokine receptor 5 (CCR5) locus in pigtailed macaque HSPCs by zinc finger nucleases (ZFNs) was feasible. We show that macaque-specific CCR5 ZFNs efficiently induce CCR5 […]

Read more

Publication Spotlight: A curative regimen would decrease HIV prevalence but not HIV incidence unless targeted to an ART-naïve population

Posted on March 1, 2016 by defeatHIV

HIV curative strategies currently under development aim to eradicate latent provirus, or prevent viral replication, progression to AIDS, and transmission. The impact of implementing curative programs on HIV epidemics has not been considered. We developed a mathematical model of heterosexual HIV transmission to evaluate the independent and synergistic impact of ART, HIV prevention interventions and […]

Read more

Publication Spotlight: Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy

Posted on February 15, 2016 by defeatHIV

Incurable chronic viral infections are a major cause of morbidity and mortality worldwide. One potential approach to cure persistent viral infections is via the use of targeted endonucleases. Nevertheless, a potential concern for endonuclease-based antiviral therapies is the emergence of treatment resistance. Here we detect for the first time an endonuclease-resistant infectious virus that is […]

Read more

Publication Spotlight: Safety and Efficacy of Combination Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Adults Undergoing Autologous or Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies

Posted on January 19, 2016 by defeatHIV

The ability to continue combination antiretroviral therapy (cART) in human immunodeficiency virus (HIV)-infected patients undergoing hematopoietic cell transplantation (HCT) for treatment of hematologic malignancies is likely a critical factor in preventing the establishment of an HIV reservoir in transplanted stem cells. Thus, we studied the feasibility of continued antiretroviral therapy in our HIV-infected patients undergoing […]

Read more

Conference on Cell and Gene Therapy for HIV Cure 2015

Posted on July 8, 2015 by defeatHIV

WEBSITE DATES August 13-14, 2015 LOCATION Fred Hutchinson Cancer Research Center Seattle, WA USA   We are pleased to announce the 2nd Conference on Cell & Gene Therapy for HIV Cure will be held August 13-14, 2015, in Seattle, WA. This conference aims to bring much needed attention to HIV cell and gene therapies by uniting an […]

Read more

defeatHIV investigator wins prestigious International AIDS Society (IAS) Award:

Posted on July 8, 2015 by defeatHIV

Dr. Christopher Peterson, staff scientist in the lab of defeatHIV Co-PI Dr. Hans-Peter Kiem at Fred Hutch, was awarded the IAS Young Investigator Award for his recent HIV Cure research. His abstract was one of over 2,500 competing for this prize, which is to be presented at this year’s annual IAS Conference on HIV Pathogenesis, […]

Read more