defeatHIV Receives Second Round of Funding from NIH

Posted on July 13, 2016 by defeatHIV
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This article was originally published on fredhutch.org: http://www.fredhutch.org/en/news/center-news/2016/07/HIV-cure-program-fred-hutch-expanded.html Fred Hutch HIV cure program extended, expanded DefeatHIV receives second five-year grant from NIH to research gene and cell therapies July 13, 2016 By Mary Engel / Fred Hutch News Service Dr. Keith Jerome, left, and Dr. Hans-Peter Kiem are the co-directors of defeatHIV. Photo by Robert […]

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Conference on Cell & Gene Therapy for HIV Cure 2016

Posted on July 12, 2016 by defeatHIV
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3rd Annual Conference on Cell & Gene Therapy for HIV Cure to be held August 4-5, 2016 in Seattle, WA WEBSITE ctg4hivcure2016.org DATES Pre-Conference Community Event: August 3, 2016 Conference: August 4-5, 2016 LOCATION Fred Hutchinson Cancer Research Center Seattle, WA USA We are pleased to announce the 3rd Conference on Cell & Gene Therapy […]

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Publication Spotlight: Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

Posted on May 28, 2016 by defeatHIV
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Genome editing in hematopoietic stem and progenitor cells (HSPCs) is a promising novel technology for the treatment of many human diseases. Here, we evaluated whether the disruption of the C-C chemokine receptor 5 (CCR5) locus in pigtailed macaque HSPCs by zinc finger nucleases (ZFNs) was feasible. We show that macaque-specific CCR5 ZFNs efficiently induce CCR5 […]

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Publication Spotlight: A curative regimen would decrease HIV prevalence but not HIV incidence unless targeted to an ART-naïve population

Posted on March 1, 2016 by defeatHIV
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HIV curative strategies currently under development aim to eradicate latent provirus, or prevent viral replication, progression to AIDS, and transmission. The impact of implementing curative programs on HIV epidemics has not been considered. We developed a mathematical model of heterosexual HIV transmission to evaluate the independent and synergistic impact of ART, HIV prevention interventions and […]

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Publication Spotlight: Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy

Posted on February 15, 2016 by defeatHIV
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Incurable chronic viral infections are a major cause of morbidity and mortality worldwide. One potential approach to cure persistent viral infections is via the use of targeted endonucleases. Nevertheless, a potential concern for endonuclease-based antiviral therapies is the emergence of treatment resistance. Here we detect for the first time an endonuclease-resistant infectious virus that is […]

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Publication Spotlight: Safety and Efficacy of Combination Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Adults Undergoing Autologous or Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies

Posted on January 19, 2016 by defeatHIV
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The ability to continue combination antiretroviral therapy (cART) in human immunodeficiency virus (HIV)-infected patients undergoing hematopoietic cell transplantation (HCT) for treatment of hematologic malignancies is likely a critical factor in preventing the establishment of an HIV reservoir in transplanted stem cells. Thus, we studied the feasibility of continued antiretroviral therapy in our HIV-infected patients undergoing […]

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Conference on Cell and Gene Therapy for HIV Cure 2015

Posted on July 8, 2015 by defeatHIV
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WEBSITE ctg4hivcure2015.org DATES August 13-14, 2015 LOCATION Fred Hutchinson Cancer Research Center Seattle, WA USA   We are pleased to announce the 2nd Conference on Cell & Gene Therapy for HIV Cure will be held August 13-14, 2015, in Seattle, WA. This conference aims to bring much needed attention to HIV cell and gene therapies by uniting an […]

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defeatHIV investigator wins prestigious International AIDS Society (IAS) Award:

Posted on July 8, 2015 by defeatHIV
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Dr. Christopher Peterson, staff scientist in the lab of defeatHIV Co-PI Dr. Hans-Peter Kiem at Fred Hutch, was awarded the IAS Young Investigator Award for his recent HIV Cure research. His abstract was one of over 2,500 competing for this prize, which is to be presented at this year’s annual IAS Conference on HIV Pathogenesis, […]

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Conference on Cell and Gene Therapy for HIV Cure 2014

Posted on May 16, 2014 by defeatHIV
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  WEBSITE ctg4hivcure2014.org DATES August 26-27, 2014 LOCATION Fred Hutchinson Cancer Research Center Seattle, WA USA We are pleased to announce the inaugural Conference on Cell & Gene Therapy for HIV Cure will be held August 26-27, 2014, in Seattle, WA. This meeting is designed to foster scientific collegiality and to continue to build the important scientific collaborations and […]

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defeatHIV CAB Meetings

Posted on May 16, 2014 by defeatHIV
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                                            Cal Anderson House 400 Broadway Seattle, WA 98112 RSVP TO: 206-667-5810 or mlouella@fhcrc.org         The defeatHIV Community Advisory Board (CAB) invites you to join us for our standing monthly meetings […]

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