Led by the Fred Hutchinson Cancer Research Center in Seattle, our participating institutions are the backbone of defeatHIV, the Delaney Cell and Genome Engineering Initiative. Fully supporting our collaboratory’s research endeavors and facilitating our scientific progress, each of our institutions provide unique and complementary strengths that are leveraged in support of the program’s activities. For example, the Hutchinson Center pioneered the clinical and scientific basis for hematopoietic cell transplantation for the treatment of malignant disease. We are now applying this therapy for the treatment of HIV infection. Hutchinson Center scientists have also been at the forefront of directed design of sequence-specific homing endonucleases, which are now being evaluated as a tool for the cure of HIV.
Learn more about our institutions and their programs below.
Fred Hutchinson Cancer Research Center
1100 Fairview Ave N
Seattle, WA 98109
Fred Hutchinson Cancer Research Center was established in 1975 and is one of the world’s leading cancer research institutes. Its interdisciplinary teams of scientists conduct research throughout the world to advance the prevention, early detection and treatment of cancer and other diseases. The Center’s mission is the elimination of cancer and related diseases as causes of human suffering and death. Hutchinson Center researchers pioneered bone-marrow transplantation for leukemia and other blood diseases. This research has cured thousands of patients worldwide and has boosted survival rates for certain forms of leukemia from zero to as high as 85 percent. Recognizing that infectious agents contribute to up to a quarter of the world’s cancers, Center researchers also study infectious diseases, including HIV- and AIDS-related malignancies. The Center’s internationally acclaimed scientists include three Nobel Laureates, a MacArthur fellow, seven members of the National Academy of Sciences, five members of the Institute of Medicine, six members of the American Academy of Arts and Sciences, 11 members of the American Association for the Advancement of Science and eight current and former Howard Hughes Medical Institute investigators.
The Hutchinson Center occupies modern facilities on the 15-acre Robert W. Day Campus. The campus overlooks South Lake Union, Seattle’s downtown lakefront neighborhood, which is emerging as Seattle’s hub for life sciences research organizations. Center labs and offices occupy about 1.3 million square feet. More than 2,750 people work for the Hutchinson Center, including more than 200 scientific faculty and more than 500 pre-doctoral and post-doctoral researchers and other scientific staff.
The Hutchinson Center is consistently among the top NCI-funded academic and research institutes and is ranked first in National Institutes of Health funding among all U.S. independent research institutions.
Beckman Research Institute of the City of Hope
1500 East Duarte Road
Duarte, CA 91010
Recognized nationwide for its innovative biomedical research, Beckman Research Institute of City of Hope is home to some of the most creative minds in science. With a staff of more than 500, including nearly 100 principal investigators, Beckman Research Institute undertakes fundamental investigations in basic biology and genetics. Here, interdisciplinary teams of investigators, from renowned researchers to postdoctoral fellows to graduate students, challenge assumptions, explore unconventional strategies and pursue new lines of inquiry in a collegial and supportive environment.
The first of only five Beckman Research Institutes established by funding from the Arnold and Mabel Beckman Foundation, the institute is responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes. Its breakthroughs in the areas of recombinant DNA technology, gene therapy and monoclonal antibodies are testaments to the culture of collaboration that inspires and informs its work.
The institute’s discoveries, and commitment to rapidly move those discoveries into clinical trials, are grounded in the institution’s history of compassion and drive to save lives and enhance the quality of lives of patients everywhere.
City of Hope is a leading research, treatment and education center for cancer, diabetes and other life-threatening diseases. Designated as a comprehensive cancer center, the highest honor bestowed by the National Cancer Institute, and a founding member of the National Comprehensive Cancer Network, City of Hope’s research and treatment protocols advance care throughout the nation. City of Hope is located in Duarte, Calif., just northeast of Los Angeles, and is ranked as one of “America’s Best Hospitals” in cancer by U.S.News & World Report. Founded in 1913, City of Hope is a pioneer in the fields of bone marrow transplantation and genetics.
The National Institutes of Health (NIH), a part of the US Department of Health and Human Services, is the nation’s medical research agency—making important discoveries that improve health and save lives.
Thanks in large part to NIH-funded medical research, Americans today are living longer and healthier. Life expectancy in the United States has jumped from 47 years in 1900 to 78 years as reported in 2009, and disability in people over age 65 has dropped dramatically in the past 3 decades. In recent years, nationwide rates of new diagnoses and deaths from all cancers combined have fallen significantly.
NIH is the largest source of funding for medical research in the world, creating hundreds of thousands of high-quality jobs by funding thousands of scientists in universities and research institutions in every state across America and around the globe.
NIH’s mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce the burdens of illness and disability.
Point Richmond Tech Center II
501 Canal Blvd
Richmond, CA 94804
Sangamo BioSciences is a clinical-stage biopharmaceutical company focused on the research, development and commercialization of engineered DNA-binding proteins as the basis of a novel therapeutic platform to address unmet medical needs.
The company is the worldwide leader in the development of proprietary technology enabling specific gene modification and regulation of gene expression. Sangamo is developing ZFP Therapeutics®, drugs designed to function at the DNA level, for treatment of indications including HIV/AIDS and several monogenic diseases. The ZFP Therapeutic platform is based on a naturally occurring class of transcription factors, zinc finger DNA-binding proteins (ZFPs), which can be engineered to bind with high specificity to DNA sequences in therapeutically relevant genes. When linked to functional domains that normally activate or repress gene expression, ZFP transcription factors (ZFP TFs) can be created that are capable of turning genes on or off. Sangamo scientists also link ZFPs to nuclease domains to create zinc finger nucleases (ZFNs) that enable precise gene-editing in cells. Engineered ZFNs can modify a cell’s DNA at a designated location to facilitating correction or disruption of a specific gene as well as the targeted addition of a new DNA sequence.
Seattle Children’s Research Institute
1900 Ninth Ave
Seattle, WA 98101
Seattle Children’s Research Institute is the research arm of Seattle Children’s Hospital, which is dedicated to preventing, treating, and eliminating pediatric disease. The research institute has nine major centers, and is internationally recognized for its work in cancer, genetics, immunology, pathology, infectious disease, injury prevention and bioethics. Between 2003 and 2005, Children’s nearly doubled its annual grant funding from the National Institutes of Health (NIH). As of 2009, it is among the top five pediatric medical research centers in terms of NIH grant funding.
In October 2006, Children’s acquired two nearly new research buildings totaling nearly 500,000 square feet, on two adjacent city blocks in downtown Seattle with a total of 1.5 million developable square feet. The adjacent buildings are located in downtown Seattle, near the heart of one of the nation’s most advanced biotechnology districts and less than 1 mile from the FHCRC. The 1900 9th Avenue building encompasses 216,088 square feet on 11 floors, four of which are outfitted for bench laboratory research, and includes a state-of-the-art barrier vivarium as well as core laboratories for flow cytometry. The 1915 Terry Avenue building provides 251,095 square feet on seven floors. Over the course of the next several years, the research institute will create nine research centers in these buildings. The facilities will have an initial staff of approximately 250, and ultimately, interdisciplinary teams totaling approximately 500 researchers will collaborate here, conducting bench research and clinical trials focusing on infectious disease, cancer, immunology and many other areas.
University of Washington
1410 NE Campus Parkway
Seattle, WA 98195
The University of Washington was founded in 1861. UW is one of the oldest state-supported institutions of higher education on the west coast and is one of the preeminent research universities in the world. The university has three campuses, with its largest campus in Seattle’s University District approximately two miles from the Hutchinson Center. Its operating budget for fiscal year 2005 was $3.1 billion. The UW occupies over 500 buildings, with over 20 million gross square footage of space. In 2010, the school placed 16th in the world’s top universities, according to the Academic Ranking of World Universities.
In 2006, the University of Washington research budget passed the $1 billion milestone. Virtually all of the funding came from peer-reviewed research proposals. The UW research budget consistently ranks among the top 5 in both public and private universities in the United States. The UW is also the largest recipient of federal research funding among public universities, and ranks second among all public and private universities in the country, a position that the university has held each year since 1974. The UW school of medicine faculty generated more than $900 million in research funds last year, with NIH grants totaling $712.3 million.
Among the UW faculty, there are five winners of Albert Lasker Award for Clinical Medical Research, one winner of the Fields Medal, five winners of the National Medal of Science, nineteen winners of the Presidential Early Career Awards in Science and Engineering, and six Nobel Prize laureates. Additionally, among UW faculty are fifty-eight members of the American Academy for Arts and Sciences, thirteen Howard Hughes Medical Institute Investigators, forty-eight members of the Institute of Medicine, fifteen members of the National Academy of Engineering, and sixty members of the National Academy of Sciences.