First defeatHIV Clinical Study Is Enrolling!
We are excited to announce recruitment for the first defeatHIV clinical study is open! This is an important step in our HIV eradication efforts and as such, we will be updating defeatHIV.org to include further information on our clinical studies for HIV patients. Read on for study details, eligibility criteria and clinic contact information.
Protocol 1410: Treatment with Allogeneic Hematopoietic Stem Cell Transplantation for Induction of Mixed Hematopoietic Chimerism in Patients Infected with Human Immunodeficiency Virus-1 Using a Non-Ablative Conditioning Regimen Containing Total Body Irradiation in Combination with Post-Transplant Immunosuppression with Cyclosporine and Mycophenolate Mofetil
Purpose: The purpose of the treatment on this study is to replace bone marrow cells with healthy cells donated by a person with a healthy immune system. The new bone marrow or hematopoietic stem cells have the ability to grow into new blood and immune systems. We believe that HAART may give us a new way to help control the HIV and prevent it from infecting the new bone marrow cells. We will monitor the level of HIV in the latent reservoir to determine whether HAART drugs can continue to control or even reduce HIV after hematopoietic stem cell transplantation (HSCT).
Major eligibility criteria:
- Patients with a hematologic malignancy in remission treatable with HSCT, who:
a. have been on HAART for at least one month, and
b. have a HIV load <5000 copies/ml.
- Or, Patients without malignancy who meet these criteria:
a. have been treated with more than one HAART regimen for at least six continuous months, and
b. have a HIV load <50 copies/ml, and c. have a CD4 count <100 cells/ml.
- Patients must have an HLA-matched donor.
- Patients must be <65 years old.
Contact: For more information, contact the Clinical Coordinator Office at the Seattle Cancer Care Alliance (1-800-804-8824) and reference protocol number 1410.
defeatHIV clinical studies are performed in Seattle, WA at the Seattle Cancer Care Alliance (SCCA). The SCCA is the treatment arm of the world-renowned Fred Hutchinson Cancer Research Center, and operates the largest bone marrow transplant program in the world.