Video: Targeting Proviral DNA as Therapy for HIV Infection – Keith Jerome – CFAR – Oct 2011
Dr. Keith Jerome discusses key strategies for targeting latent HIV as a therapy for disease in the University of Washington / Fred Hutchinson Cancer Research Center, Center for AIDS Research (CFAR) seminar series.
From Dr. Jerome:
“Chronic viral infections have plagued humanity for millennia. Now infections such as HIV are being targeted by new approaches that raise the possibility of their cure. In this talk, I explain the use of DNA editing enzymes such as zinc finger nucleases and homing endonucleases to disrupt essential viral nucleic acids, or the human genes encoding receptors needed for viral entry. I also discuss the potential of this approach for other viruses, including hepatitis B virus, herpes simplex virus, and human papillomavirus, and the challenges ahead in bringing this technology into the clinic for therapeutic use.”